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International Journal of Pharmacognosy and Herbal Drug Technology

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📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

📢 Latest Update: New special issue call for papers on "Emerging Technologies in Research" - Submit by March 31, 2025

IJPHDT, Vol-2, Issue-9, Sep-2025

Volume 2, Issue 9 - undefined 2025

Volume 2 Issue 9 Cover

Issue Details:

Volume 2 Issue 9
Published:Invalid Date

Editorial: IJPHDT, Vol-2, Issue-9, Sep-2025

Welcome to the 2025 issue of International Journal of Pharmacognosy and Herbal Drug Technology. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Margaret Thompson
Editor-in-Chief
International Journal of Pharmacognosy and Herbal Drug Technology

Articles in This Issue

Showing 8 of 8 articles
Research PaperID: IJPHD-00000153

Adaptogenic Herbs in Ayurvedic Medicine: Pharmacognostic Insights and Clinical Potential

Mudit Kumar, Minakshi verma, Sachin Kumar, Yatindra Kumar, Brajesh Kumar

Adaptogens are a special type of medicinal plant used to treat the effects of stress and stimulate the body to respond to stress better. In Ayurveda, herbal rasayana drugs include Withania somnifera (Ashwagandha), Ocimum sanctum (Tulsi), Tinospora cordifolia (Guduchi), and Glycyrrhiza glabra (Yashtimadhu), thus these drugs are thought to have rejuvenative effects. This review presents a summary of the pharmacognostic details and preclinical (animal) evidence of these herbs with focus on morphological, microscopic and phytochemical characteristics and the stress modulating effects of these herbs. In animals, there is a consistent effect demonstrating that these adaptogens normalize the hypothalamic-pituitary-adrenal axis, recover antioxidant defenses, lower corticosterone and other markers of oxidative stress, and enhance behavioral and immunological resistance. The data confirm conventional assertions and note their neuroprotective, immunomodulatory and anti-stressive effects. Nonetheless, loopholes exist as far as the aspect of standardization, dose optimization, adverse effects in the long term, and mechanism of action of phytoconstituents are concerned. In conclusion, this review highlights the potential therapeutic value of Ayurvedic adaptogens as natural, clinically safe therapeutic agents, and demands rigorous and mechanistic research to incorporate them into evidence-based medicine.

Gallic acidmicrocomposite gelschitosan-alginate matriceswound healingcontrolled drug deliveryionic gelation+1 more
9,650 views
2,958 downloads

Contributors:

 Mudit Kumar
,
 Minakshi verma
,
 Sachin Kumar
,
 Yatindra Kumar
,
 Brajesh Kumar
Research PaperID: IJPHD-00000160

Antimicrobial Activity of Selected Medicinal Plant Extracts

Komal Kriti

The bioactive properties, chemicals produced by plants have a potential alternative to antibiotic-resistant infections which are increasingly becoming common. Standardized extraction techniques were used to meticulously synthesize medicinal plant extracts, which were then given to the study subjects using an in vivo animal model. A thorough assessment of the extracts' inhibitory effects was provided by tracking microbial development in different tissues and counting colony-forming units to determine the antimicrobial efficacy. To ascertain the significance of the observed differences between the treatment and control groups, data were analyzed using exacting statistical techniques. The findings showed that some plant extracts have strong antibacterial properties and successfully inhibit microbial growth in the animal model. These results provide important new information about the preclinical uses of medicinal plants and highlight their therapeutic potential as a supplement or substitute for traditional antibiotics. Additionally, this study lays the groundwork for further research that will isolate active ingredients, clarify mechanisms of action, and assess safety profiles in order to further the development of plant-based antimicrobial treatments.

central sensitization.chronic painTENSexercise therapynon-pharmacological interventionspain modulation+1 more
10,133 views
3,033 downloads

Contributors:

 Komal Kriti
Research PaperID: IJPHD-00000151

Development and Evaluation of Herbal based Moisturizing Cream

Saurabh Shrivastava, Akash Dewangan Dewangan, Nikhil Kumar Dewangan

Abstract: This study presents the formulation and evaluation of an herbal-based moisturizing cream using ginger (Zingiber officinale), honey (Madhu), and pomegranate (Punica granatum), chosen for their antioxidant, anti-inflammatory, humectant, and skin-rejuvenating properties. The cream was prepared by the fusion method and developed into seven formulations (F1–F7), evaluated for appearance, pH, viscosity, spreadability, washability, stability, and irritation. Among them, F5 showed the most suitable characteristics, with a pH of 5.3, viscosity of 108.3 mPa·s, excellent spreadability (2.5 cm²/sec), and easy washability without irritation. The results suggest herbal creams are safe, effective, and sustainable alternatives to synthetic moisturizers.

Translational research.Targeted deliveryPharmacodynamicsPharmacokineticsConventional dosage formsNano-enabled drug carriers+2 more
9,892 views
2,900 downloads

Contributors:

 Saurabh Shrivastava
,
 Akash Dewangan Dewangan
,
 Nikhil Kumar Dewangan
Research PaperID: IJPHD-00000161

Evaluation of Anti-Inflammatory Activity of Plant-Based Compounds

Sujit Ramchandra Deshmukh, Mayuri Shatrughna Ghadge, Ajay Vitthal Nalawade, Ravindra Raghunath Mahajan

The current work used the carrageenan-induced paw edema model in Wistar rats to determine the anti-inflammatory properties of plant-based substances, namely quercetin (Ficus carica) and curcumin (Curcuma longa). Four groups of 24 rats each were created: Quercetin, Curcumin, Standard Drug (Diclofenac), and Negative Control. The volume of paw edema was measured one, two, three, and four hours after induction. Diclofenac showed the greatest suppression of paw swelling at all time periods, while carrageenan was able to successfully produce inflammation in the control group, according to the results. When compared to the control, both curcumin and quercetin considerably decreased inflammation; however, the difference was not statistically significant, with curcumin being slightly more efficient than quercetin. The trustworthiness of these findings was validated by statistical analysis. According to the study's findings, quercetin and curcumin have strong anti-inflammatory properties and could be useful natural supplements or substitutes for traditional synthetic medications.

In Vivo StudyPlant ExtractsAnimal ModelAntimicrobial ActivityMedicinal Plants
9,986 views
3,037 downloads

Contributors:

 Sujit Ramchandra Deshmukh
,
 Mayuri Shatrughna Ghadge
,
 Ajay Vitthal Nalawade
,
 Ravindra Raghunath Mahajan
Research PaperID: IJPHD-00000162

Integration of Herbal Drugs in Modern Healthcare Systems

Sneha Tejram Gahane, Jayashri Bhumeshwar Telmasare, Shruti N. Parshuramkar, Kundlik Girhepunje

The application of herbal drugs has become an extensive part of the human history because the drug has been in use since centuries and all over the continents of Ayurveda in India, Traditional Chinese Medicine (TCM), to the traditional African and Native American medicine systems because the drug has been the major provider of health care before the emergence of synthetic drugs. However, the systematic adoption into health care systems has not been expeditious, consistent and consistent enough so as to be able to hold an adjuvative or substitute position, but not necessarily fit in the mainstream clinical practice. It is a literature review of the evolving role of herbal medicine in contemporary healthcare based on critical analysis of existing literature on its effectiveness, safety, pharmacological and regulatory acceptability in other locations. Such points are historical concepts, treatment role in the management of the chronic and lifestyle-based condition, advances in the clinical research, the persisting issues of standardization and quality control, and the potential of the national and international regulatory body to ensure authenticity and safety.

DiclofenacPlant-based compoundsCarrageenan-induced paw edemaQuercetinCurcuminAnti-inflammatory activity
10,491 views
3,225 downloads

Contributors:

 Sneha Tejram Gahane
,
 Jayashri Bhumeshwar Telmasare
,
 Shruti N. Parshuramkar
,
 Kundlik Girhepunje
Research PaperID: IJPHD-00000157

Novel Therapeutic Mediators: The Intersection of Pharmacognosy and Ethnopharmacology

Rajesh Dudhmal, Sunil K Mahajan, Chandrashekhar Patil, Durgesh Pagar, Dipti Chavan

Methodically screening and successfully validating new natural materials as medicines begins with the intersection of these two fields, ethnopharmacology and pharmacognosy. New natural remedies have been developed as a result of traditional knowledge of plants, minerals, and animals. Ethnomedicine is the source of many of the most clinically significant medications used today, including morphine, quinine, and artemisinin. The pharmacological properties, modes of action, and safety profiles of bioactive chemicals are evaluated by controlled, biopharmaceutical, pre-clinical, and in vivo research. There is substantial evidence of bioactives (such as flavonoids, terpenoids, polyphenols, alkaloids, saponins, and resveratrol) modulating corresponding molecular pathways, as well as regulating enzyme activity and receptor interactions, as well as large-scale anti-inflammatory, antioxidant, antimicrobial, antidiabetic, and anticancer activity. Although animal experiments are excellent for reproducibility and mechanistic insights, they are complicated by interspecies heterogeneity, extract variability, bioavailability, and ethical issues that call for additional in vitro, computer model, and clinical trials. Standardised extracts, the creation of bioactive formulations that target multiple modes of action, and the environmentally responsible sourcing of medicinal plants that connect traditional and modern pharmacotherapy should be the main priorities of the future. These studies demonstrate the translational potential of agents derived from ethnopharmacology, validating the wisdom of our ancestors' traditions while also offering the chance to safely explore beneficial phytotherapeutics to meet the health care needs of contemporary society.

Hydroxypropyl Methylcellulose (HPMC).Poloxamer 188Poloxamer 407Nanosized antiviral agentsThermoresponsive in-situ nasal gelQuality-by-Design (QbD)
10,043 views
3,107 downloads

Contributors:

 Rajesh Dudhmal
,
 Sunil K Mahajan
,
 Chandrashekhar Patil
,
 Durgesh Pagar
,
 Dipti Chavan
Research PaperID: IJPHD-00000178

Phytochemical and Antifungal Investigation of the Plant of Caryot Urens

Kaminee Potai, Arpan Kumar Tripathi, Vikas Kumar Sahu

The present study evaluated the antifungal potential of methanolic bark and leaf extracts of Caryota urens (family: Arecaceae), a palm species traditionally used in folk medicine. Extracts were prepared and screened against Trichoderma asperellum using the disc diffusion method, with Amphotericin B (180 µg/disc) serving as the positive control. Preliminary phytochemical analysis revealed the presence of flavonoids, alkaloids, tannins, phenols, and saponins, compounds known for their antimicrobial properties. Both extracts exhibited moderate antifungal activity in a dose-dependent manner. At 1000 µg/disc, the leaf extract produced an inhibition zone of 7 mm, whereas the bark extract showed stronger activity with zones of 9–10 mm. In comparison, Amphotericin B produced a 10 mm inhibition zone at a lower concentration, confirming its higher potency. These findings suggest that C. urens possesses bioactive constituents with antifungal activity, particularly in the bark, and highlight its potential as a natural source for the development of novel antifungal agents.

10,452 views
3,219 downloads

Contributors:

 Kaminee Potai
,
 Arpan Kumar Tripathi
,
 Vikas Kumar Sahu
Research PaperID: IJPHD-00000163

Role of Herbal Drugs in Wound Healing Mechanisms

Shubham Kamble, Tirupati Rasala, Bhagyashri Barewar, Pranjali Meshram, Ankita Kale, Gayatri Kasdekar

Wound healing is a complex and dynamic biological process and involves hemostasis, inflammation, proliferation, and remodeling of tissues that can be impaired by factors like infection, oxidative stress, and chronic inflammation. Surveying herbal drugs, which have been reported to be high in bioactive phytoconstituents such as flavonoids, terpenoids, alkaloids, tannins and phenolic drugs, have become effective in wound repair acceleration. Preclinical animal models suggest that Curcuma longa, Ocimum sanctum, Centella asiatica and Azadirachta indica extracts have significant effect on wound contraction, collagen deposition, angiogenesis, fibroblast proliferation and general tissue regeneration and decreasing oxidative damage, inflammation and microbial burden. The combination of such multifaceted microenvironmental biological activities results in a supportive microenvironment that promotes quicker and more effective wound healing, which is why they may be evaluated as cost-effective, biocompatible, and culturally acceptable alternatives or complements to traditional synthetic therapeutics. Although showing good preclinical outcomes, there are still issues of standardization of the extraction processes, doses and formulations as well as scanty clinical confirmation in humans. Such studies should be backed up by future studies in which rigorous clinical trials and molecular level mechanistic studies are performed with optimization of the delivery systems to convert these studies into safe, effective, and standard therapeutic modalities in modern wound management.

Herbal medicines; Modern healthcare integration; Complementary and alternative medicine (CAM); Phytotherapy; Standardization challenges
10,435 views
3,208 downloads

Contributors:

 Shubham Kamble
,
 Tirupati Rasala
,
 Bhagyashri Barewar
,
 Pranjali Meshram
,
 Ankita Kale
,
 Gayatri Kasdekar

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