International Journal of Pharmacognosy and Herbal Drug Technology

The antibacterial, anti-inflammatory, and wound-recovery houses of a polyherbal methanolic extract (PHME) made from Argemone mexicana, Datura stramonium, and Plumbago zeylanica are tested in this study. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa had been the 4 bacterial traces towards which the antibacterial pastime of PHME became assessed in vitro the use of techniques such as broth dilution and agar well diffusion. In assessment to the diverse plant extracts, the consequences indicated that PHME had the bottom minimal inhibitory concentrations (MICs) and the widest zones of inhibition, indicating its higher antibacterial effectiveness. According to the examine, PHME's antibacterial performance became on par with that of the commonplace antibiotic, Ofloxacin, particularly whilst it came to Staphylococcus aureus. The antibacterial pastime of PHME become drastically extra than that of the separate extracts, in line with statistical analysis. These consequences mean that PHME has wonderful healing promise alternatively for traditional antibiotics, with potential makes use of in wound healing and the treatment of bacterial infections. To completely inspect its healing variety and medical utility, greater research is needed.

The study reports the anticancer activity of the methanolic extract of Eclipta alba on two human colon cancer cell lines, namely HCT-116 and HT-29. In simple terms, the objectives of the research include the cytotoxic efficacy of the extract, its capability to inhibit cellular migration, and its importance in colony formation. The extract showed significant cytotoxic effects on its subordinates with IC₅₀ values ranging between 200 to 400 μg/mL in an array of assays used, such as MTT, wound healing, and clonogenic assays. There is impressive selectivity toxicity since it can spare the normal fibroblast cells-WI-38. This is a proof that it can be especially defined as an anticancer drug. Furthermore, the results have established that the extract has the ability to inhibit cancer cell migration and colony formation; therefore, it can functionally represent such a potential for the very crucial cancer treatment and prevention of metastasis. These observations are consistent with the previous study, and this fosters the vision that Eclipta alba is a potentially useful drug from nature as a natural medicinal drug. For further studies, its application should be developed for cancer therapy with research based on its bioactive combinations, subatomic components, and in vivo adequacy.

This study investigates the anti-ulcer potential of Osyris quadripartita leaf extract using albino Wistar rats as an experimental model. The extract was prepared by Soxhlet extraction with methanol and its efficacy was evaluated in both ethanol and indomethacin-induced ulcer models, which simulate different ulcerogenesis mechanisms. Rats were treated with varying doses of the extract (100, 200, and 400 mg/kg) for 7 days, alongside a standard group receiving omeprazole. The outcomes were assessed through gastric juice pH measurement, ulcer index scoring, and histological examination of gastric tissue. Results showed a dose-dependent reduction in ulcer severity and an increase in gastric pH, suggesting enhanced mucosal protection. The 400 mg/kg dose demonstrated comparable effectiveness to omeprazole. The study provides scientific evidence supporting the gastroprotective properties of Osyris quadripartita, highlighting its potential as a natural remedy for peptic ulcer.