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International Journal of Pharmacognosy and Herbal Drug Technology

Published

Evaluation of Anti-Ulcer Activity of The Leaf Extract of Osyris Quadripartita Decne. (Santalaceae) In Rats

Published in IJPHDT, Vol-1, Issue-1, Dec-2025 (Vol. 1, Issue 1, 2025)

Evaluation of Anti-Ulcer Activity of The Leaf Extract of Osyris Quadripartita Decne. (Santalaceae) In Rats - Issue cover

Abstract

This study investigates the anti-ulcer potential of Osyris quadripartita leaf extract using albino Wistar rats as an experimental model. The extract was prepared by Soxhlet extraction with methanol and its efficacy was evaluated in both ethanol and indomethacin-induced ulcer models, which simulate different ulcerogenesis mechanisms. Rats were treated with varying doses of the extract (100, 200, and 400 mg/kg) for 7 days, alongside a standard group receiving omeprazole. The outcomes were assessed through gastric juice pH measurement, ulcer index scoring, and histological examination of gastric tissue. Results showed a dose-dependent reduction in ulcer severity and an increase in gastric pH, suggesting enhanced mucosal protection. The 400 mg/kg dose demonstrated comparable effectiveness to omeprazole. The study provides scientific evidence supporting the gastroprotective properties of Osyris quadripartita, highlighting its potential as a natural remedy for peptic ulcer.

Authors (2)

Pritam Bhore

SPMs Charak College of Pharmacy and Research, Wagholi Pune

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Arpan Tripathi

KIPS, Shrishankaracharya Professional University, (C.G). India

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Article Information

Article ID:
IJPHD-00000012
Paper ID:
IJPHD-01-000012

How to Cite

, P. & Tripathi (2025). Evaluation of Anti-Ulcer Activity of The Leaf Extract of Osyris Quadripartita Decne. (Santalaceae) In Rats. International Journal of Pharmacognosy and Herbal Drug Technology, 1(1), xx-xx. https://ijphdt.scholarjms.com/articles/3

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