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International Journal of Pharmacognosy and Herbal Drug Technology

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Exploring The Synergistic Effects of Plant-Derived Compounds with Conventional Antibiotics Against MDR Strains

Published in IJPHDT, Vol-2, Issue-8, Aug-2025 (Vol. 2, Issue 8, 2025)

Exploring The Synergistic Effects of Plant-Derived Compounds with Conventional Antibiotics Against MDR Strains - Issue cover

Abstract

Multidrug-resistant (MDR) bacterial pathogens are emerging and becoming a dire concern, and researchers are dependent on innovative solutions to the problem to reestablish antibiotic susceptibility. This paper examined synergisitc influences of plant-derived agents chosen to comprise of a conventional antibiotic against MDR pathogens. Phytochemicals had moderate anti-microbial activity against the same bacteria when administered separately, and their combination with antibiotics resulted in marked elevation of antimicrobial activity, decreased minimum inhibitory effect (MIC) and postponed resistance development. Bactericidal activity was demonstrated to be sustained over time by time-kill assays and cytotoxicity testing showed positive safety ratios at synergistic concentrations. These results were also justified statistically. Generally, these findings indicate the therapeutic potential value of phytochemical-antibiotic combination in curbing the menace of antimicrobial resistance as a cost effective and a sustainable method of managing this global emergency.

Authors (3)

Hiren Ravindra Shirsath

S.S.Agrawal College of Commerce and Management, Navsari, Gujarat., Pin- 396445

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Prachi Kamleshbhai Pandya

S.S.Agrawal College of Commerce and Management, Navsari, Gujarat., Pin- 396445

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Twisha Mehulkumar Patel

S.S.Agrawal College of Commerce and Management, Navsari, Gujarat., Pin- 396445

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Article Information

Article ID:
IJPHD-00000126
Paper ID:
IJPHD-01-000126

How to Cite

Hiren Ravindra Shirsath & Prachi Kamleshbhai Pandya & Twisha Mehulkumar Patel (2025). Exploring The Synergistic Effects of Plant-Derived Compounds with Conventional Antibiotics Against MDR Strains. International Journal of Pharmacognosy and Herbal Drug Technology, 2(8), xx-xx. https://ijphdt.scholarjms.com/articles/57

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