Phytochemical Screening and Anti-Ageing Potential of Herbal Extracts in A Topical Cream Formulation

Background: Calendula, chamomile, and butterfly pea contain a high concentration of antioxidants that rejuvenate skin and provide relief from irritation. Based on this information, we can assume that extracts of these plants can be used to make a sustainable anti-aging cream as a natural alternative to existing skincare products. Objective: This research aims to formulate a topical cream using extracts of calendula, chamomile, and butterfly pea. The work also includes tests of the phytochemical profile and evaluation parameters of the cream. Materials and Methods: In this study, we assessed the content of flavonoids, phenolics, tannins, saponins, and alkaloids by performing qualitative phytochemical screening on methanolic extracts of Clitoria ternatea, Calendula officinalis, and Matricaria chamomilla. Using standard methods, we emulsified the mixed herbal extracts to produce an oil-in-water cream. Once prepared, the cream formulation was evaluated for organoleptic properties, pH, viscosity, homogeneity, spreadability, and stability under a variety of storage conditions. Results: All three herbal extracts were shown to have significant quantities of phenolic compounds and flavonoids upon phytochemical analysis. Additionally, the formulated cream proved to have desirable organoleptic qualities that include a pH of 4.5- 5.2, stable viscosity, and good spreadability. It also proved to remain homogeneous with no evidence of phase separation or microbial growth over the duration of the 30-day stability study. Conclusion: Anti-aging cream formulation using butterfly pea, calendula, and chamomile extracts exhibited promising physical, chemical, and stability profiles. The phytochemical components support the viability of its use as a natural anti-aging formulation. Further studies to assess its biological efficacy are recommended.