Evaluation of Dose-Dependent Hepatoprotective Effects of a Novel Polyherbal Extract in Wistar Rats

The study's aim is to assist science-based traditional medicine by assessing a polyherbal extract's capacity to protect the liver at varying doses in rats with CCl4-induced liver damage. Four adult male rat groups were used in an experimental investigation with random grouping. Three of the four groups received CCl4 together with either a high or low dose of polyherbal extract, whereas one group simply received CCl4. In addition to microscopic examination of necrosis, inflammation, and liver cell regeneration, liver damage was assessed using ALT, AST, ALP, and bilirubin assays. It was found that CCl4 severely harmed the liver, with more enzymes in blood and worse tissue degeneration, but higher amounts of the polyherbal extract successfully lessened these adverse effects. Also, the high-dose group largely recovered, as seen by nearly normal enzyme levels, little dead tissue, and many regenerating hepatocytes. Using ANOVA, the results were shown to be significant (p