Arpan Tripathi

Nephrolithiasis, also referred to as kidney stone disease, is a major worldwide health issue, and the most common form is calcium oxalate. The application of medicinal herbs in its prevention and treatment has attracted significant interest because of their bioactive constituents with antiurolithic activity. In this review, in vivo studies on rat models of calcium oxalate nephrolithiasis are critically assessed systematically to determine the efficacy of medicinal herbs. The review identifies major herbs, their mechanisms of action, experimental results, and possible clinical uses. Results indicate that most medicinal herbs have nephroprotective, antioxidant, anti-inflammatory, and diuretic effects, which help in decreasing stone formation and recurrence. More studies are required to standardize the dosages and confirm their efficacy in human trials.

This study investigates the anti-ulcer potential of Osyris quadripartita leaf extract using albino Wistar rats as an experimental model. The extract was prepared by Soxhlet extraction with methanol and its efficacy was evaluated in both ethanol and indomethacin-induced ulcer models, which simulate different ulcerogenesis mechanisms. Rats were treated with varying doses of the extract (100, 200, and 400 mg/kg) for 7 days, alongside a standard group receiving omeprazole. The outcomes were assessed through gastric juice pH measurement, ulcer index scoring, and histological examination of gastric tissue. Results showed a dose-dependent reduction in ulcer severity and an increase in gastric pH, suggesting enhanced mucosal protection. The 400 mg/kg dose demonstrated comparable effectiveness to omeprazole. The study provides scientific evidence supporting the gastroprotective properties of Osyris quadripartita, highlighting its potential as a natural remedy for peptic ulcer.