Volume 2, Issue 2 - undefined 2025
Welcome to the 2025 issue of International Journal of Pharmacognosy and Herbal Drug Technology. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.
We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.
As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.
Dr. Margaret Thompson
Editor-in-Chief
International Journal of Pharmacognosy and Herbal Drug Technology
Antimalarial treatments, Artemisinin-based Combination Therapies (ACTs), parasite load reduction, randomized control trial, Neem extract, chloroquine-resistant strains
Nephrolithiasis, also referred to as kidney stone disease, is a major worldwide health issue, and the most common form is calcium oxalate. The application of medicinal herbs in its prevention and treatment has attracted significant interest because of their bioactive constituents with antiurolithic activity. In this review, in vivo studies on rat models of calcium oxalate nephrolithiasis are critically assessed systematically to determine the efficacy of medicinal herbs. The review identifies major herbs, their mechanisms of action, experimental results, and possible clinical uses. Results indicate that most medicinal herbs have nephroprotective, antioxidant, anti-inflammatory, and diuretic effects, which help in decreasing stone formation and recurrence. More studies are required to standardize the dosages and confirm their efficacy in human trials.
The integration of nanotechnology with herbal medicine has revolutionized drug delivery by addressing major problems with traditional herbal preparations' irregular therapeutic effectiveness, rapid metabolism, and poor bioavailability. Bioactive herbal compounds have been enhanced in solubility, stability, and controlled release due to nanocarriers like liposomes, polymeric nanoparticles, solid lipid nanoparticles (SLNs), dendrimers, and nanoemulsions. This provides targeted delivery with reduced systemic toxicity. With these advances, the therapeutic value of herbal-based medicines for chronic diseases such as cancer, cardiovascular disease, neurological disorders, and microbial infections has significantly enhanced. Besides enhancing herbal medicine absorption and efficacy, nanotechnology-based drug delivery systems also meet the increasing demand for natural and biocompatible treatments globally. They are not generally employed in the clinic, however, due to hindrances such as high production costs, scalability issues, complex regulatory environment, and potential long-term toxicity. Creation of biodegradable nanocarriers, extensive in vivo and clinical studies, and artificial intelligence application for optimizing drug formulation and delivery systems must be the primary focus of future work. Development of drug delivery systems that integrate the advantages of nanotechnology and herbal medicine could make the way to more individualized and targeted therapeutics. In order for nano-herbal drug delivery systems to enter into clinical trials and become successful, interdisciplinary collaboration and technological advances will be necessary in order to address existing challenges. This will enhance healthcare outcomes globally and revolutionize modern pharmacotherapy.
Diabetes and hyperlipidemia are among the biggest worldwide health issues and are the causative factors behind many chronic ailments and complications. Polyherbal formulations from traditional medicine hold much promise as an alternative or complement to orthodox medication. This investigation sought to compare the antidiabetic and antihyperlipidemic properties of a polyherbal drug in streptozotocin-induced diabetic rats, in addition to checking for any possible herb-drug interactions with metformin. Results indicated that the polyherbal drug lowered blood glucose levels remarkably, enhanced lipid profiles, and showed no adverse interactions with antidiabetic medication metformin. The findings indicate the therapeutic potential of the polyherbal drug in controlling diabetes and hyperlipidemia with a good safety profile. Additional clinical trials are suggested to validate these effects in human subjects and investigate the mechanisms of action of the herbs in the formulation.
Oral health is an essential aspect of general well-being, but widespread conditions like dental caries, gingivitis, periodontitis, and halitosis are still prevalent. Traditional treatments like fluoride-based products and antibiotics have been effective but are associated with limitations like antibiotic resistance, side effects, and high expense. This review discusses the possibility of herbal remedies as alternatives to traditional oral health care. Different herbs, such as neem, clove, turmeric, and aloe vera, have antimicrobial, anti-inflammatory, and analgesic activities that could be responsible for enhanced oral health and disease control. Based on a review of the available literature, this paper emphasizes the effectiveness, mechanisms, and limitations of incorporating herbal medicine into conventional dental practice.
The medicinal plants Cinnamomum cassia, Berberis vulgaris, Curcuma longa, Vitex agnus-castus and Glycyrrhiza glabra have shown potential in treating PCOS symptoms effectively with limited unwanted consequences. The review demonstrates an extensive analysis of PCOS pathophysiology together with an assessment of established treatment methods and an examination of rising herbal therapy significance. More extensive clinical trials need to be conducted to confirm suitable treatment dosages and determine long-lasting safety norms and reveal treatment mechanism details of herbal medicine. The combination of proven herbal treatments with conventional therapy alongside personalized medical care would establish an advanced method for treating PCOS that enhances the effectiveness of reproductive and metabolic health management.
