Anticancer activity

One of the leading causes of cancer-related death for women worldwide is breast cancer. Natural substances obtained from therapeutic plants, particularly terpenoids, have garnered considerable interest as potential sources for pharmaceuticals. This study aims to determine which plant-based terpenoids, when tested in vitro against MCF-7 and MDA-MB-231, exhibit anti-cancer properties. Terpenoids were extracted using conventional chromatographic methods, and their identification was confirmed using spectroscopic analysis. We used fluorescence microscopy and flow cytometry to detect apoptotic effects and the MTT assay to measure cytotoxicity. The findings demonstrated that the dose affected the effects of apoptosis induction and cancer cell growth inhibition. The authors of the study believe that terpenoids from plants have a lot of potential as a treatment for breast cancer.

The study reports the anticancer activity of the methanolic extract of Eclipta alba on two human colon cancer cell lines, namely HCT-116 and HT-29. In simple terms, the objectives of the research include the cytotoxic efficacy of the extract, its capability to inhibit cellular migration, and its importance in colony formation. The extract showed significant cytotoxic effects on its subordinates with IC₅₀ values ranging between 200 to 400 μg/mL in an array of assays used, such as MTT, wound healing, and clonogenic assays. There is impressive selectivity toxicity since it can spare the normal fibroblast cells-WI-38. This is a proof that it can be especially defined as an anticancer drug. Furthermore, the results have established that the extract has the ability to inhibit cancer cell migration and colony formation; therefore, it can functionally represent such a potential for the very crucial cancer treatment and prevention of metastasis. These observations are consistent with the previous study, and this fosters the vision that Eclipta alba is a potentially useful drug from nature as a natural medicinal drug. For further studies, its application should be developed for cancer therapy with research based on its bioactive combinations, subatomic components, and in vivo adequacy.