Deleshwar Kumar

The study's aim is to assist science-based traditional medicine by assessing a polyherbal extract's capacity to protect the liver at varying doses in rats with CCl4-induced liver damage. Four adult male rat groups were used in an experimental investigation with random grouping. Three of the four groups received CCl4 together with either a high or low dose of polyherbal extract, whereas one group simply received CCl4. In addition to microscopic examination of necrosis, inflammation, and liver cell regeneration, liver damage was assessed using ALT, AST, ALP, and bilirubin assays. It was found that CCl4 severely harmed the liver, with more enzymes in blood and worse tissue degeneration, but higher amounts of the polyherbal extract successfully lessened these adverse effects. Also, the high-dose group largely recovered, as seen by nearly normal enzyme levels, little dead tissue, and many regenerating hepatocytes. Using ANOVA, the results were shown to be significant (p

Today Pharmacognosy functions as an essential scientific basis for discovering anticancer medications through research of natural medicating plants alongside additional natural resources. The article evaluates the vital role which pharmacognosy plays when developing compounds that act as cancer treatments. The article describes extraction techniques alongside screening and characterization protocols that help researchers find anticancer compounds among bioactive plant principles. The discovery of pharmacological agents’ taxol and camptothecin and vinca alkaloids stands as one of the primary outcomes alongside their subsequent development into medicinal drugs. The scope includes modern screening procedures linked with molecular docking approaches along with biotechnological growth that enhances both efficiency and pharmaceutical research outcomes in pharmacognosy. The review addresses difficulties alongside existing trends and future guidance about employing natural products for developing oncological drugs.

being a major contributor to liver damage. The present review has focused attention on the antioxidant and hepatoprotective properties of standardised herbal extracts, which can represent a natural and sustainable solution for liver health. Standardisation makes it possible to ensure consistency in the concentration of bioactive compounds, enhancing the reliability and efficacy of these herbal remedies. Key extracts, such as silymarin from Silybum marianum, curcumin from Curcuma longa, and lignans from Phyllanthus amarus, exhibit strong antioxidant properties by scavenging free radicals, preventing lipid peroxidation and regulating inflammatory pathways. Their clinical and preclinical evidence has proved them to be effective in treating liver diseases such as non-alcoholic fatty liver disease, drug-induced liver injury, and viral hepatitis. Despite their promises, some hurdles still face them, including variability in raw materials, low bioavailability, and regulatory gaps. This review calls for further optimization of bioavailability as well as the synergistic effects of phytochemicals along with the availability of global regulatory standards to establish standardized herbal extracts as effective integrative therapeutic options for liver health.

This study investigates the neuroprotective effects of a new herbal extract using a rat model of Parkinson's disease. A total of 100 male Wistar rats were employed in this study, dividing the animals into five groups: one for control, one for PD, and three for low, moderate, and high dosages of the herbal remedy. Behavioural tests of rotarod and open field, biochemical analysis for dopamine levels and markers of oxidative stress, and histological assessments for surviving dopaminergic neurons were done for four successive weeks. Improvements in motor coordination, reductions in oxidative stress, increase in dopamine levels, and survival of dopaminergic neurons showed significant improvements within herbal remedy-treated groups, with high doses showing the most pronounced effect.