biocompatibility

Adaptogens are a special type of medicinal plant used to treat the effects of stress and stimulate the body to respond to stress better. In Ayurveda, herbal rasayana drugs include Withania somnifera (Ashwagandha), Ocimum sanctum (Tulsi), Tinospora cordifolia (Guduchi), and Glycyrrhiza glabra (Yashtimadhu), thus these drugs are thought to have rejuvenative effects. This review presents a summary of the pharmacognostic details and preclinical (animal) evidence of these herbs with focus on morphological, microscopic and phytochemical characteristics and the stress modulating effects of these herbs. In animals, there is a consistent effect demonstrating that these adaptogens normalize the hypothalamic-pituitary-adrenal axis, recover antioxidant defenses, lower corticosterone and other markers of oxidative stress, and enhance behavioral and immunological resistance. The data confirm conventional assertions and note their neuroprotective, immunomodulatory and anti-stressive effects. Nonetheless, loopholes exist as far as the aspect of standardization, dose optimization, adverse effects in the long term, and mechanism of action of phytoconstituents are concerned. In conclusion, this review highlights the potential therapeutic value of Ayurvedic adaptogens as natural, clinically safe therapeutic agents, and demands rigorous and mechanistic research to incorporate them into evidence-based medicine.