Neha Mandle

The experimental analysis of Syzygium cumini extract pharmacodynamic properties examines blood glucose control mechanisms and antioxidant effects and tests security parameters. For 28 days Wistar rats with streptozotocin-induced diabetes received Syzygium cumini extract treatment at both 200 mg/kg and 400 mg/kg doses. Blood glucose levels decreased substantially during the study period while the high-dose treatment group achieved near-normal glucose concentrations by its conclusion. The antioxidant function of the extract occurred due to elevated reduced glutathione (GSH) together with higher superoxide dismutase (SOD), catalase levels and decreased malondialdehyde (MDA). Tests of lipid profile showed higher HDL values and lower levels of total cholesterol and triglycerides and LDL which could protect the heart. The test of liver enzymes validated a good safety profile for the extract because it yielded negative hepatotoxicity results. Test outcomes demonstrate that Syzygium cumini extract may function as an additional treatment to manage diabetes together with its connected complications and protect the cardiovascular system.

This research is a comparative study of various extraction techniques to improve alkaloid yield and purity from medicinal plants. Alkaloids, with their broad spectrum of pharmacological activities including anticancer, analgesic, and antimalarial activities, are key bioactive molecules in pharmaceutical uses. The research assesses both traditional extraction methods—maceration and Soxhlet—and innovative techniques—Microwave-Assisted Extraction (MAE), Ultrasound-Assisted Extraction (UAE), Accelerated Solvent Extraction (ASE), and Solid Phase Extraction (SPE). Three medicinal plants rich in alkaloids (Rauwolfia serpentina, Catharanthus roseus, and Papaver somniferum) were chosen for the investigation. The techniques were evaluated on the basis of yield percentage, extraction time, solvent usage, and purity of extracts (evaluated through HPLC). Findings indicated that ASE and MAE performed significantly better than conventional techniques, providing higher purity and yield with less time and solvent consumption. SPE, employed as a purification process, also enhanced the quality of extracts. The findings support eco-friendly, new extraction methods in pharmaceutical and biotechnology, offering effective alternatives to existing approaches. The research standardizes alkaloid extraction methods for natural product research and industry.

The disorders that affect the liver are a significant contributor to the morbidity and mortality rates that are experienced all over the world. Due to its natural bioactive chemicals, its cost-effectiveness, and the fact that it has fewer adverse effects, herbal medicine has gained popularity as a complementary and alternative strategy. It discussed the details regarding the important medicinal herbs including the hepatoprotective effects of milk thistle, turmeric, and liquorice, the mechanism of actions and clinical efficacies in relation to a potential application within strategies to address liver disease management. Despite the promising, there is also a lot pointed out by its problems that it has-standardisation, interactions of herbs with drugs and limited large scale trials. This way forwards to more avenues of further research.